- Title
- A review of psilocybin: chemistry, clinical uses and future research directions
- Creator
- Milliken, Eliza; Galettis, Peter; Martin, Jenny
- Relation
- Australian Journal of Chemistry Vol. 76, Issue 5, p. 258-263
- Publisher Link
- http://dx.doi.org/10.1071/CH23010
- Publisher
- C S I R O Publishing
- Resource Type
- journal article
- Date
- 2023
- Description
- Classic psychedelics such as psilocybin, ketamine and lysergic acid diethylamide (LSD) are 5HT2A serotonin receptor agonists that produce individualised subjective affects. Today, public interest in psychedelic medicine has reached a fervour but the evidence for clinical benefit still lags. Psilocybin and psilocin are tryptophan based alkaloids found worldwide in mushrooms of the genera Psilocybe, Panaeolus, Conocybe, Gymnopilus, Stropharia, Pluteus and Panaeolina. This review addresses the current evidence base for psilocybin as a clinical medicine, the general chemistry and proposed mechanism of its therapeutic effect and future research directions for psilocybin based therapies.
- Subject
- addiction; altered protein expression; anxiety; brain-derived neurotrophic factor release; depression; executive network inhibition
- Identifier
- http://hdl.handle.net/1959.13/1483143
- Identifier
- uon:51077
- Identifier
- ISSN:0004-9425
- Rights
- © 2023 The Author(s) (or their employer(s)). Published by CSIRO Publishing. This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND). (https://creativecommons.org/licenses/by-nc-nd/4.0/).
- Language
- eng
- Full Text
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